The public health relevance of hangover is in its potential effects on occupational safety and performance. Apart from pharmacological effects of ethanol and congeners, psychosocial factors also contribute to morning-after feelings, particularly the emotions of shame and guilt. Tobacco smoking increases the hangover’s incidence and severity, explained by pharmacological effects of nicotine and other smoke constituents. During a drinking binge, many people would smoke more than usual; some intermittent smokers or those who gave up would restart. The hangover “curing” with beer or vodka the next morning (hair of the dog) may contribute to negative affectivity in the long run, as it implies a cycle of alcohol consumption and shame. Some individuals experience a temporary symptomatic relief after a hair of the dog drink. According to our observations, if the “curing” is accompanied by smoking, the elevated mood in some people would more easily shift to dysphoria, irritation or depression. Psychological mechanisms thereof are discussed here. Besides, the problem of smoking in psychiatric hospitals is briefly discussed. In conclusion, smoking can exacerbate hangover symptoms through both toxicological and psychosocial mechanisms. The problem of smoking in the settings of alcoholism and mental health problems should be further investigated.